SANTA CLARA, Calif. (AP) — Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an injury to his throwing shoulder that has already forced him to miss a game. Purdy spent the bulk of the session of Wednesday's practice open to reporters as either a spectator or executing handoffs outside of one short pass to Jordan Mason. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.
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Shares of Arrowhead Pharmaceuticals Inc. ($ARWR) and Sarepta Therapeutics Inc. ($SRPT) climbed on Wednesday despite Wall Street trimming price targets after the companies announced a $1 billion licensing agreement. Under the deal, Sarepta gains exclusive global rights to multiple programs targeting rare genetic diseases affecting muscles, the central nervous system, and lungs. In return, Arrowhead will receive $825 million upfront, comprising $500 million in cash and $325 million in equity at a 35% premium. An additional $250 million will be paid in installments over the next five years. Arrowhead is also eligible for up to $10 billion in potential milestones and low double-digit royalties. Needham lowered Sarepta’s price target to $202 from $205, maintaining a ‘Buy’ rating. But the brokerage praised the deal for its platform diversification and alignment with Sarepta’s rare genetic medicine expertise. Piper Sandler cut Arrowhead’s price target to $45 from $62, keeping an ‘Overweight’ rating. The brokerage sees the collaboration as transformative, with Sarepta acquiring clinical and preclinical TRiM programs. Piper also reduced Sarepta’s price target to $182 from $200, highlighting the partnership’s pipeline expansion and near-term financial impact. Citi reduced Arrowhead’s price target to $26 from $27, maintaining a ‘Neutral’ stance. The analyst noted Arrowhead’s extended cash runway through 2028, aided by this deal and a strategic financing arrangement with Sixth Street. Arrowhead ranked among the top 10 trending symbols on Stocktwits by Wednesday afternoon, with a good dose of optimistic retail chatter driving activity for both stocks. However, a bearish overhang remains for Arrowhead after it missed fiscal fourth-quarter expectations on Tuesday, reporting a loss of $1.36 per share (vs. a $0.97 loss consensus) and $35 million in revenue (vs. $55.07 million expected). Arrowhead’s CEO emphasized the company’s readiness to commercialize medicines, spotlighting the recent submission of its first New Drug Application (NDA) to the FDA for plozasiran, which could launch in 2025 pending approval. Year-to-date, Arrowhead shares have declined over 14%, while Sarepta has surged more than 40%. For updates and corrections email newsroom[at]stocktwits[dot]com. US President-elect Donald Trump has announced that retired Army general Keith Kellogg will be his special envoy for Ukraine and Russia. Trump is scheduled to be sworn in as the 47th US president on January 20 next year. He has already announced dozens of names of future officials, some of whom need to be approved by the Senate first. “He was with me right from the beginning,” Trump wrote on his Truth Social platform on Wednesday, announcing Kellogg’s nomination. “Together, we will secure peace through strength and make America, and the world, safe again!” Kellogg served as chief of staff for the National Security Council during Trump’s first presidential term (2017-2021). He was a top aide to then-Vice President Mike Pence and acting national security advisor to Trump after the ouster of General Michael Flynn in February 2017. ”I don’t think World War III has begun, but we’re right on the precipice,” Kellogg told Fox News last week , after President Joe Biden authorized long-range missile strikes into Russia. He described the conflict as “the largest land war in Europe since the end of WWII,” where a single spark “can spin things right out of control, without even trying.” Kellogg did not criticize the White House for making the missile decision, however, saying that it would give Trump “more leverage” to negotiate come January. Richard Grenell, the former US ambassador to Germany and Trump’s former acting director of national intelligence, had also been a candidate for the job. According to Reuters, Kellog and another former Trump aide, Fred Fleitz, co-authored the proposal for ending the Russia-Ukraine conflict that Vice President-elect JD Vance outlined in a September interview. The plan would freeze the conflict along the current line of confrontation without recognizing Russia’s sovereignty over territories claimed by Ukraine, while putting off consideration of Kiev’s membership in NATO for a future date. Moscow would be forced to the negotiating table by a threat of US increasing its aid to Kiev, while Ukraine would get a promise of more American weapons if it agreed to the talks. Both Russia and Ukraine have dismissed the rumored proposal as a non-starter, however. Kellogg served in the US Army and was chief of staff of the 82nd Airborne Division during the first Gulf War (1990-1991). After the 2003 US invasion of Iraq, he was appointed chief operating officer of the occupation authority in Baghdad. The Costco Guys brought the "Boom" to All Elite Wrestling. Content creators Andrew "Big Boom AJ" Befumo, with his 11-year-old son Big Justice in his corner, as well as viral sensation The Rizzler, defeated AEW wrestler Q.T. Marshall at AEW Full Gear in New Jersey on Saturday night. Editor's Picks From MJF and Rhea to...a Viking? Here are the 30 best pro wrestlers under 30 1y Marc Raimondi and Brandon Caldwell AEW live televised and PPV events schedule 21d AEW current world champions and title history 21d The match ended when Big Justice entered the ring and speared Marshall, followed by a PowerBoom by AJ for the victory. Big Boom AJ previously worked as an independent professional wrestler under the name "the American Powerchild Eric Justice." The Costco Guys have over 2.3 million followers on TikTok. Their song "We Bring the BOOM!" has over a million views on their official YouTube channel -- and over 1,300 posts on TikTok have used it in their videos. "We have such a great time making our TikToks, making our YouTube videos, meeting with some of the greatest creators in the world," AJ said at the AEW Full Gear post show media scrum . "I just always knew with professional wrestling, when you come through that curtain, and you feel that connection with the audience, especially here in my home state of New Jersey, there's no greater feeling in the world." AEW founder and co-owner Tony Khan, who is also an executive with the NFL's Jacksonville Jaguars and Premier League club Fulham (both of which his father Shad Khan is the owner), praised the Costco Guys and their involvement with AEW: "They are marketing geniuses. It's amazing to me that this whole phenomenon of Costco Guys and Big Boom AJ, Big Justice and The Rizzler, this has all been happening for less than a year, (AJ) started this in January. He built something so strong, a social media empire in months. For the people here in AEW, we can relate to that, because we also work in something that we built from the ground up as a family." When asked if AJ will wrestle again, he responded: "I love it here (in AEW). I loved every minute of this. If I'm welcomed back, I'm gonna be back, and I'm gonna bring the Boom!" AJ did note that because of their busy schedule creating content, an extended run may not be in their future plans, but "to wrestle multiple times throughout the year and see where that goes, I think that's kind of more the direction I'm leaning."(All times Eastern) Schedule subject to change and/or blackouts Saturday, Nov. 23 AUSTRALIAN RULES FOOTBALL (WOMEN’S) 3:30 a.m. FS2 — AFL Playoffs: Adelaide at Brisbane, Preliminary Final AUTO RACING 12:55 a.m. (Sunday) ESPN — Formula 1: The Heineken Silver Las Vegas Grand Prix, Las Vegas Strip Circuit, Las Vegas COLLEGE BASKETBALL (MEN’S) Noon FS2 — St. Francis (Pa.) at Georgetown 5 p.m. FS2 — N. Illinois at DePaul COLLEGE BASKETBALL (WOMEN’S) 4 p.m. NBC — Notre Dame at Southern Cal PEACOCK — Notre Dame at Southern Cal COLLEGE CROSS COUNTRY (MEN’S and WOMEN’S) 9:30 a.m. ESPNU — NCAA Championships: From Verona, Wis. COLLEGE FOOTBALL Noon ABC — Mississippi at Florida ACCN — UConn at Syracuse BTN — Iowa at Maryland CBSSN — Sam Houston St. at Jacksonville St. CW — North Carolina at Boston College ESPN — Wake Forest at Miami ESPN2 — SMU at Virginia ESPNU — Yale at Harvard FOX — Indiana at Ohio St. PEACOCK — Illinois at Rutgers 12:45 p.m. SECN — UMass at Georgia 3:30 p.m. ABC — Kentucky at Texas ACCN — Stanford at California BTN — Wisconsin at Nebraska CBS — Penn St. at Minnesota CBSSN — San Diego St. at Utah St. CW — The Citadel at Clemson ESPN — BYU at Arizona St. ESPNU — UCF at West Virginia FOX — Colorado at Kansas FS1 — Northwestern at Michigan 4 p.m. ESPN2 — Pittsburgh at Louisville 4:15 p.m. SECN — Missouri at Mississippi St. 7 p.m. CBSSN — Boise St. at Wyoming CW — Washington St. at Oregon St. FS1 — Baylor at Houston NBC — Army vs. Notre Dame, New York PEACOCK — Army vs. Notre Dame, New York 7:30 p.m. ABC — Alabama at Oklahoma ESPN — Texas A&M at Auburn ESPNU — Marshall at Old Dominion FOX — Iowa St. at Utah 7:45 p.m. SECN — Vanderbilt at LSU 8 p.m. ACCN — Virginia Tech at Duke ESPN2 — Cincinnati at Kansas St. 10:15 p.m. NBC — Southern Cal at UCLA 10:30 p.m. CBSSN — Colorado St. at Fresno St. FS1 — Air Force at Nevada 11 p.m. ESPNU — Florida A&M at Bethune-Cookman (Taped) COLLEGE VOLLEYBALL (WOMEN’S) 8 p.m. BTN — Wisconsin at Nebraska GOLF 1 p.m. GOLF — PGA Tour: The RSM Classic, Third Round, Sea Island Golf Club - Seaside Course, Sea Island, Ga. 4 p.m. GOLF — LPGA Tour: The CME Group Tour Championship, Third Round, Tiburon Golf Club, Naples, Fla. (Taped) 9:30 p.m. GOLF — DP World Tour: The BMW Australian PGA Championship, Final Round, Royal Queensland Golf Club, Brisbane, Australia 1 a.m. (Saturday) GOLF — Asian Tour: The LINK Hong Kong Open, Final Round, Hong Kong Golf Club, Hong Kong HORSE RACING 11:30 a.m. FS1 — NYRA: America’s Day at the Races 3:30 p.m. FS2 — NYRA: America’s Day at the Races 1 a.m. (Sunday) FS2 — The Japan Cup: From Tokyo Racecourse, Tokyo NBA BASKETBALL 5 p.m. NBATV — New York at Utah 8 p.m. NBATV — Memphis at Chicago 10:30 p.m. NBATV — Denver at L.A. Lakers NHL HOCKEY 1 p.m. NHLN — Chicago at Philadelphia 7 p.m. NHLN — Vegas at Montreal SAILING 5 a.m. CBSSN — Sail GP: The Emirates Dubai Sail Grand Prix - Day 1, Dubai, United Arab Emirates 5 a.m. (Sunday) CBSSN — Sail GP: The Emirates Dubai Sail Grand Prix - Day 2, Dubai, United Arab Emirates SOCCER (MEN’S) 7:30 a.m. USA — Premier League: Chelsea at Leicester City 9 a.m. CBSSN — Serie A: Inter Milan at Hellas Verona 10 a.m. USA — Premier League: Brighton & Hove Albion at Bournemouth Noon CBS — USL Championship: Rhode Island at Colorado Springs, Final 12:30 p.m. NBC — Premier League: Tottenham Hotspur at Manchester City 7 p.m. FS2 — Saudi Pro League: Al Hilal at Al Khaleej (Taped) SOCCER (WOMEN’S) 8 p.m. CBS — NWSL Playoffs: Orlando vs. Washington, Final, Kansas City, Mo. TENNIS 7 a.m. TENNIS — Davis Cup Finals Semifinal The Associated Press created this story using technology provided by Data Skrive TV listings provided by LiveSportsOnTV . (All times Eastern) Schedule subject to change and/or blackouts Sunday, Nov. 24 COLLEGE BASKETBALL (MEN’S) 10:30 a.m. ESPNU — ESPN2 — Myrtle Beach Invitational: TBD, Seventh-Place Game, Conway, S.C. 11 a.m. CBSSN — St. John’s vs. Georgia, Nassau, Bahamas 1 p.m. CBSSN — Rutgers at Kennesaw St. ESPN — Villanova vs. Maryland, Newark, N.J. ESPN2 — Myrtle Beach Invitational: TBD, Third-Place Game, Conway, S.C. 3 p.m. CBSSN — Greenbrier Tip-Off: TBD, Third-Place Game, West White Sulphur Springs, W.V. ESPN — Charleston Classic: TBD, Third-Place Game, Charleston, S.C. 3:30 p.m. ESPN2 — Florida St. vs. UMass, Uncasville, Conn. 5:30 p.m. CBSSN — Greenbrier Tip-Off: TBD, Championship, West White Sulphur Springs, W.V. ESPN — Myrtle Beach Invitational: TBD, Championship, Conway, S.C. 6 p.m. ESPN2 — Charleston Classic: TBD, Fifth-Place Game, Charleston, S.C. ESPNU — Yale vs. Delaware, Uncasville, Conn. 8 p.m. ESPN2 — Myrtle Beach Invitational: TBD, Fifth-Place Game, Conway, S.C. 8:30 p.m. ESPN — Charleston Classic: TBD, Championship, Charleston, S.C. COLLEGE BASKETBALL (WOMEN’S) 1 p.m. PEACOCK — South Florida vs. Louisville, Lake Buena Vista, Fla. 4 p.m. ACCN — Bethune-Cookman at Virginia BTN — Washington St. at Iowa FS1 — South Carolina at UCLA COLLEGE FIELD HOCKEY 1:30 p.m. ESPNU — NCAA Tournament: TBD, Championship, Ann Arbor, Mich. COLLEGE FOOTBALL 12:30 p.m. ESPNU — FCS Football Selection Show COLLEGE VOLLEYBALL (WOMEN’S) Noon ACCN — Stanford at North Carolina 2 p.m. ACCN — California at Duke SECN — South Carolina at Tennessee 3:30 p.m. ESPNU — Southwestern Athletic Tournament: TBD, Championship, Grambling, La. 4 p.m. SECN — Arkansas at Kentucky 6 p.m. SECN — Auburn vs. Oklahoma 7:30 p.m. BTN — Indiana at Ohio St. 8:30 p.m. ESPNU — Mid-Eastern Athletic Tournament: TBD, Championship, Dover, Del. FIGURE SKATING 4 p.m. NBC — ISU: The 2024 Cup of China, Chongqing, China GOLF 1 p.m. GOLF — PGA Tour: The RSM Classic, Final Round, Sea Island Golf Club - Seaside Course, Sea Island, Ga. NBC — LPGA Tour: The CME Group Tour Championship, Final Round, Tiburon Golf Club, Naples, Fla. HORSE RACING Noon FS1 — NYRA: America’s Day at the Races 4 p.m. FS2 — NYRA: America’s Day at the Races NBA G-LEAGUE BASKETBALL 1 p.m. NBATV — Capital City at Maine NFL FOOTBALL 1 p.m. CBS — Regional Coverage: New England at Miami, Tampa Bay at N.Y. Giants, Kansas City at Carolina, Tennessee at Houston FOX — Regional Coverage: Minnesota at Chicago, Detroit at Indianapolis, Dallas at Washington 4:05 p.m. CBS — Denver at Las Vegas 4:25 p.m. FOX — Regional Coverage: San Francisco at Green Bay, Arizona at Seattle 8:20 p.m. NBC — Philadelphia at L.A. Rams PEACOCK — Philadelphia at L.A. Rams NHL HOCKEY 7 p.m. NHLN — Utah at Toronto SAILING 5 a.m. CBSSN — Sail GP: The Emirates Dubai Sail Grand Prix - Day 2, Dubai, United Arab Emirates SOCCER (MEN’S) 9 a.m. USA — Premier League: Liverpool at Southampton 11:30 a.m. USA — Premier League: Manchester United at Ipswich Town 11:45 a.m. FS2 — Saudi Pro League: Al Fateh at Al Ittihad Noon ABC — Spanish Primera Division: Real Madrid at CD Leganés 6 p.m. FS1 — MLS Cup Western Conference Semifinal: Minnesota at L.A. Galaxy TENNIS 10 a.m. TENNIS — Davis Cup Finals Championship The Associated Press created this story using technology provided by Data Skrive TV listings provided by LiveSportsOnTV .